Carcinoma (cancer) and CBD/ THC/CBG

Rick Simpson ulje -izrada

What is cancer?

Carcinoma (cancer) and CBD/ THC/CBG

Cancer is a disease of body cells. Normal cells grow and multiply in a controlled manner, however, sometimes cells become abnormal and continue to grow. Abnormal cells can form a mass called a tumor. Most cancers, some 90-95% of cases, are the result of genetic mutations caused by environmental factors and lifestyle. The remaining 5–10% is the result of inherited genetics. Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries. In 2015, about 90.5 million people worldwide had cancer, and in 2019, the annual number of cancer cases increased by 23.6 million people.

Breast cancer in women and lung cancer in men are the most commonly diagnosed cancers and the leading cause of cancer death for each gender.

The most common types of cancer:

  • Lung cancer
  • Colon cancer
  • Prostate cancer
  • Stomach cancer
  • Cervical cancer

The risk of developing certain types of cancer can be reduced by not smoking, maintaining a healthy body weight, limiting alcohol intake, eating lots of vegetables, fruits and whole grains, getting vaccinated against certain infectious diseases, limiting the consumption of processed meat and red meat, and limiting exposure to direct sunlight. .

Signs and symptoms:

Cancer symptoms can be non-specific changes in an individual’s sense of physical well-being (constitutional symptoms) or they can be localized to a specific organ system or anatomical area.

  • Unexplained weight loss: Weight loss that is unintentional and not explained by diet, exercise, or other illness can be a warning sign of many types of cancer.
  • Unexplained pain: Pain that persists, has no clear cause, and does not respond to treatment can be a warning sign of many types of cancer.
  • Unexplained fatigue: Unusual and persistent fatigue may indicate an underlying disease, including blood cell cancers such as leukemia or lymphoma.
  • Unexplained night sweats or fever: These can be signs of cancer of the immune system. Fever in children rarely indicates malignancy, but may merit evaluation.

How Cancer and CBD/THC/CBG work

Cannabidiol (CBD) is one of the main components of the Cannabis sativa plant. Surveys show that medical cannabis is popular among people diagnosed with cancer. CBD is one of the key constituents of cannabis and does not have the potentially intoxicating effects of tetrahydrocannabinol (THC), another key phytocannabinoid.

Research shows that CBD (full-spectrum) may have the potential to treat cancer, including symptoms and signs associated with cancer and its treatment. Preclinical studies suggest that CBD may affect many pathways involved in cancer pathogenesis. Preclinical and clinical research also indicates some evidence of efficacy, alone or in some cases in combination with tetrahydrocannabinol (THC, the other key phytocannabinoid in cannabis), in the treatment of cancer-related pain, anxiety and depression, sleep problems, nausea and vomiting, and oral mucositis associated with cancer and/or its treatment.

Studies also suggest that CBD can enhance orthodox chemotherapy and radiation therapy treatments and protect against nerve and organ damage. CBD holds promise as part of an integrative approach to cancer treatment.

Both THC and CBD share many therapeutic effects, but their mechanisms of action differ. THC is a partial agonist of CB1 and CB2 receptors, similar to AEA. However, CBD has a low affinity for cannabinoid receptors and is believed to exert its effects mainly through indirect activation of the ECS (endocannabinoid system), as well as interaction with other targets or receptors.

Therapeutic effects of CBD:

  • Pain reliever
  • Against nausea
  • Antiemetic
  • Anxiolytic
  • Antidepressant
  • Antipsychotic
  • Anticonvulsant/antiepileptic
  • Antiasthmatic immunomodulatory
  • Antioxidant
  • Anti-inflammatory
  • Antibiotic, antibacterial
  • Against cancer
  • Neuroprotective

Various preclinical studies, from null cell line studies to rodent cancer models, have revealed that various cannabinoids (including the endocannabinoids AEA, 2-AG, the phytocannabinoids THC, CBD, and synthetic cannabinoid receptor agonists) have anticancer activity. Cannabinoid effects include cell cycle arrest, induction of apoptosis, inhibition of chemotaxis, cancer cell migration, adhesion, angiogenesis, invasion and metastasis. CBD can modulate the tumor microenvironment, reducing cytokine secretion from cancer cells. Reduced recruitment of macrophages from the tumor microenvironment by cancer cells suppresses angiogenesis within the tumor, limiting the supply of oxygen and nutrients necessary for tumor growth.

In short, CBD, when it reaches a cancer cell or some other cell that is not part of our organism, wraps (cocoons) around it, giving it no chance to grow and spread further, thus stopping any contact of the diseased cell with our body and eventually expels it completely from the body, either through coughing, urination or stool.

So, in layman's terms, cannabinoids (full spectrum - THC, CBD, CBG, etc.) prevent and treat cancer cells, but knowledge is required about the varieties of plants to be used, and how to take the cannabinoid oil.

Dear readers, in the following blogs we will write about topics related to certain types of cancer and the impact of CBD on them.

Carcinoma (cancer) and CBD/ THC/CBG

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